White House chief economic adviser Larry Kudlow told reporters that one of O'Brien's daughters also contracted Covid-19 and that's how he believes he got it.

A senior administration official told CNN that O'Brien has been working from home since last week. A source familiar said O'Brien was last in the office last Thursday, when he abruptly left the White House. The White House statement said there is "no risk of exposure to the President or the Vice President."

White House chief economic adviser Larry Kudlow told reporters that one of O'Brien's daughters also contracted Covid-19 and that's how he believes he got it.

The National Security Council chief was accompanied on the trip to Europe by Secret Service agents, staffers and multiple reporters. Multiple pictures released from the trip showed O'Brien neither practicing social distancing nor wearing a mask.

As the pandemic has spread, the President has defended not wearing a mask or social distancing, with many of his top officials and White House staffers following suit, saying that it's not necessary because they are tested every day. O'Brien's positive test underscores the unique challenges of keeping the virus away from the West Wing and the President's immediate orbit.

Last week, administration officials were alerted that a cafeteria employee on White House grounds had tested positive. Kimberly Guilfoyle, the President's son's girlfriend and top campaign fundraising official, tested positive before a trip to Mt. Rushmore earlier this month. Multiple Secret Service agents and campaign staffers tested positive after becoming infected while preparing for the President's Tulsa campaign rally in June. Vice President Mike Pence's communications director Katie Miller tested positive for coronavirus in May, and one of the President's personal valets tested positive earlier that week.

O'Brien, Trump's fourth national security adviser, has been largely out of sight during the coronavirus pandemic. CNN has previously reported that rather than helping to lead the administration's response, he has delegated responsibilities to top aides and even bypassed coronavirus task force meetings.

Trump tapped O'Brien, a former lawyer and hostage negotiator, to the post in September 2019, one week after he fired John Bolton amid disagreements on foreign policy issues.

This story has been updated with additional developments Monday.